Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 16/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.41 |
| ▸ | FAP | Q12884 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345763 | 0.89 | DPP4 (0.53) | HDAC2DPP4DPP8DPP9FAP | |
| SCHEMBL18461798 | 0.85 | DPP4 (0.57) | HDAC2DPP4DPP8DPP9FAP | |
| SCHEMBL14326434 | 0.85 | DPP4 (0.57) | HDAC2DPP4DPP8DPP9FAP | |
| SCHEMBL14326148 | 0.85 | DPP4 (0.57) | HDAC2DPP4DPP8DPP9FAP | |
| Trifluoroacetic Acid SCHEMBL2495000 | 0.85 | HDAC2 (0.46) | HDAC2DPP4DPP8FAPHRH3 | |
| Trifluoroacetic Acid SCHEMBL17422955 | 0.79 | CYP2D6 (0.48) | DPP4DPP8DPP9 | |
| Trifluoroacetic Acid SCHEMBL19064900 | 0.79 | CYP2D6 (0.48) | DPP4DPP8DPP9 | |
| Trifluoroacetic Acid SCHEMBL5068417 | 0.79 | CYP2D6 (0.48) | DPP4DPP8DPP9 | |
| Trifluoroacetic Acid SCHEMBL2712122 | 0.75 | DPP4 (0.62) | DPP4 | |
| SCHEMBL15075931 | 0.74 | DPP4 (0.49) | HDAC2DPP4DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | HDAC2 324/4885DPP4 2704/4885DPP8 2961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.