Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.66 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463558 | 0.85 | BACE1 (0.64) | BACE1KCNH2BACE2 | |
| SCHEMBL2463250 | 0.83 | BACE1 (0.69) | BACE1KCNH2BACE2 | |
| SCHEMBL2462889 | 0.80 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL2464176 | 0.80 | BACE1 (0.77) | BACE1KCNH2BACE2 | |
| SCHEMBL2465648 | 0.80 | BACE1 (0.77) | BACE1KCNH2BACE2 | |
| SCHEMBL2463319 | 0.80 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL2499171 | 0.80 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL2469832 | 0.80 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL2463723 | 0.76 | BACE1 (0.64) | BACE1KCNH2BACE2 | |
| SCHEMBL2466670 | 0.75 | BACE1 (0.64) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030500-B2 | Substituted isoindoles for the treatment and/or prevention of Aβ- related pathologies | ASTRAZENECA AB (SE) | 2011-10-04 | — | — | US | disclosed |