Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.63 |
| ▸ | NPM1 | P06748 | 13/20 | 0.63 |
| ▸ | INSR | P06213 | 13/20 | 0.63 |
| ▸ | JAK2 | O60674 | 6/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518000 | 0.92 | ALK (0.66) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL521530 | 0.78 | ALK (0.70) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL521665 | 0.78 | ALK (0.78) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL520797 | 0.77 | ALK (0.62) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL520261 | 0.77 | JAK2 (1.00) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL520190 | 0.77 | ALK (0.68) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL518916 | 0.76 | JAK2 (1.00) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL521200 | 0.76 | ALK (0.75) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL521199 | 0.76 | ALK (0.75) | ALKNPM1INSRJAK2PTK2 | |
| SCHEMBL519561 | 0.76 | ALK (0.81) | ALKNPM1INSRJAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |