⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339 | 0.89 | — | — | |
| SCHEMBL23044067 | 0.89 | — | — | |
| SCHEMBL27688441 | 0.80 | — | — | |
| SCHEMBL6113934 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL27474265 | 0.80 | — | — | |
| Water SCHEMBL25365379 | 0.80 | — | — | |
| Bromide SCHEMBL27827082 | 0.80 | — | — | |
| SCHEMBL11038950 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL9799153 | 0.80 | — | — | |
| Hydrogen Sulfide SCHEMBL28222002 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109867645-A | A kind of synthetic method of 2,2- bis- fluoro- 2,3- dihydro substitution benzofuran compounds | 中国医学科学院药物研究所 | 2019-06-11 | — | — | CN | claimed |
| US-8623883-B2 | 4-phenylamino-quinazolin-6-yl-amides | WARNER-LAMBERT COMPANY LLC (US) | 2014-01-07 | — | — | US | disclosed |
| US-20130274275-A1 | 4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES | WARNER-LAMBERT COMPANY LLC | 2013-10-17 | — | — | US | disclosed |
| US-8466165-B2 | 4-phenylamino-quinazolin-6-yl-amides | WARNER-LAMBERT COMPANY LLC (US) | 2013-06-18 | — | — | US | disclosed |
| EP-1746999-B1 | 4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES | WARNER LAMBERT CO (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110262877-A1 | HEAT TREATMENT APPARATUS | IHI CORPORATION (JP) | 2011-10-27 | — | — | US | disclosed |
| US-7772243-B2 | 4-phenylamino-quinazolin-6-yl-amides | WARNER-LAMBERT COMPANY LLC (US) | 2010-08-10 | — | — | US | disclosed |
| US-20100190977-A1 | 4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| US-7307185-B2 | Process for producing optically active fluorochemical | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2007-12-11 | — | — | US | disclosed |
| US-20050250761-A1 | such as -Piperidin-1-yl-but-2-enoic acid [4(3-chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yl]-amide, used as tyrosine kinase inhibitors, for the prevention of proliferative diseases, including cancer, atherosclerosis, restenosis, endometriosis and psoriasis | PFIZER INC | 2005-11-10 | — | — | US | disclosed |
| CN-1140167-A | Process for preparing substituted 2-amino tetrahydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 1997-01-15 | — | — | CN | disclosed |
| EP-0007600-B1 | ALPHA-DIFLUOROMETHYL AMINO ACIDS AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1983-05-11 | — | — | EP | disclosed |
| EP-0007600-A1 | Alpha-difluoromethyl amino acids and pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1980-02-06 | — | — | EP | disclosed |