Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PAM | P19021 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL4890091 | 0.97 | TSHR (0.46) | TSHRHPGDTDP1THRBKDM4E | |
| Methacrylic Acid SCHEMBL12490542 | 0.94 | TSHR (0.49) | TSHRHPGDTDP1THRBKDM4E | |
| SCHEMBL2711046 | 0.91 | TSHR (0.52) | TSHRHPGDTDP1THRBKDM4E | |
| Methacrylic Acid SCHEMBL51273 | 0.89 | TSHR (0.44) | TSHRHPGDTDP1THRBKDM4E | |
| Methacrylic Acid SCHEMBL1523709 | 0.88 | TSHR (0.41) | TSHRHPGDTDP1THRBKDM4E | |
| Acrylamide SCHEMBL11418371 | 0.87 | TSHR (0.46) | TSHRHPGDTDP1THRBKDM4E | |
| SCHEMBL2462249 | 0.85 | TSHR (0.42) | TSHRHPGDTDP1THRBKDM4E | |
| SCHEMBL2499528 | 0.85 | TSHR (0.42) | TSHRHPGDTDP1THRBKDM4E | |
| SCHEMBL10951061 | 0.82 | TSHR (0.50) | TSHRHPGDTDP1THRBKDM4E | |
| SCHEMBL5386590 | 0.82 | TDP1 (0.47) | TSHRTDP1KDM4EPAMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486597-B2 | Toner, and method for producing the same | RICOH COMPANY, LTD. (JP) | 2013-07-16 | — | — | US | disclosed |
| US-20110244383-A1 | TONER, AND METHOD FOR PRODUCING THE SAME | RICOH COMPANY, LTD. (JP) | 2011-10-06 | — | — | US | disclosed |