Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 18/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.40 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25033888 | 1.00 | POLB (0.41) | POLBCRBNDDB1IKZF3DRD2 | |
| SCHEMBL25033883 | 0.91 | POLB (0.41) | POLBCRBNDDB1IKZF3DRD2 | |
| SCHEMBL25033942 | 0.91 | POLB (0.41) | POLBCRBNDDB1IKZF3DRD2 | |
| SCHEMBL25033945 | 0.90 | CRBN (0.41) | POLBCRBNDDB1IKZF3DRD2 | |
| SCHEMBL25033890 | 0.90 | CRBN (0.41) | POLBCRBNDDB1IKZF3DRD2 | |
| SCHEMBL25033943 | 0.86 | DDB1 (0.53) | CRBNDDB1 | |
| SCHEMBL25033886 | 0.86 | DDB1 (0.53) | CRBNDDB1 | |
| SCHEMBL30981016 | 0.85 | POLB (0.48) | POLBCRBNDDB1 | |
| SCHEMBL30981090 | 0.85 | POLB (0.48) | POLBCRBNDDB1 | |
| SCHEMBL30981259 | 0.85 | POLB (0.48) | POLBCRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |