Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.57 |
| ▸ | BRD4 | O60885 | 10/20 | 0.57 |
| ▸ | BRDT | Q58F21 | 6/20 | 0.57 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.49 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.48 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.48 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.48 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | NEK4 | P51957 | 1/20 | 0.48 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PDXK | O00764 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1560565 | 0.92 | PLK1 (0.62) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL25825472 | 0.92 | PLK1 (0.61) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1560601 | 0.89 | PLK1 (0.55) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30965546 | 0.87 | PLK1 (0.61) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1560493 | 0.85 | PLK1 (0.59) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1560796 | 0.84 | PLK1 (0.62) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1559373 | 0.83 | PLK1 (0.60) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL25031476 | 0.83 | PLK1 (0.54) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL25031480 | 0.82 | PLK1 (0.50) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30501310 | 0.82 | PLK1 (0.50) | PLK1BRD4BRDTPLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017442-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |