Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.49 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.37 |
| ▸ | FEN1 | P39748 | 6/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035490 | 0.92 | ERN1 (0.49) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL25035554 | 0.91 | ERN1 (0.51) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL25035529 | 0.90 | ERN1 (0.50) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL25034109 | 0.87 | BRAF (0.49) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL25035614 | 0.86 | BRAF (0.49) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL25035390 | 0.85 | BRAF (0.47) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL25034128 | 0.85 | ERN1 (0.48) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL25035487 | 0.85 | ERN1 (0.47) | ERN1BRAFALOX5APFEN1PIK3CA | |
| SCHEMBL22200616 | 0.84 | ERN1 (0.65) | ERN1BRAF | |
| SCHEMBL30242216 | 0.84 | ERN1 (0.65) | ERN1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047209-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AND METHODS OF USE | PARAZA PHARMA, INC. (CA) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047209-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AND METHODS OF USE | TYMP, TYMS, DPYD | ERN1 3167/4885BRAF 563/4885BTK 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.