Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 7/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | PRF1 | P14222 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035543 | 0.88 | PIK3CA (0.43) | PIK3CAMTORSLC40A1FEN1ALOX5AP | |
| SCHEMBL25035456 | 0.85 | PIK3CA (0.45) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL25035528 | 0.84 | PIK3CA (0.44) | PIK3CAMTORSLC40A1FEN1ALOX5AP | |
| SCHEMBL25034103 | 0.83 | PIK3CA (0.48) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL29356229 | 0.83 | ERN1 (0.53) | ALPL | |
| SCHEMBL22191165 | 0.83 | ERN1 (0.53) | ALPL | |
| SCHEMBL22191167 | 0.83 | ERN1 (0.53) | ALPL | |
| SCHEMBL25035516 | 0.79 | PIK3CA (0.44) | PIK3CAMTORFEN1ALOX5AP | |
| SCHEMBL25034132 | 0.79 | PIK3CA (0.45) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL25034118 | 0.77 | ERN1 (0.50) | PIK3CAMTORFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047209-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AND METHODS OF USE | PARAZA PHARMA, INC. (CA) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047209-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AND METHODS OF USE | TYMP, TYMS, DPYD | PIK3CA 211/4885MTOR 487/4885ALPL 2131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.