Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 6/20 | 0.40 |
| ▸ | TYK2 | P29597 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30175753 | 1.00 | ABL1 (0.45) | ABL1HRH3BRD4ATAD2JAK2 | |
| SCHEMBL23332369 | 0.88 | JAK2 (0.46) | ABL1HRH3BRD4ATAD2JAK2 | |
| SCHEMBL30175712 | 0.88 | JAK2 (0.46) | ABL1HRH3BRD4ATAD2JAK2 | |
| SCHEMBL30175742 | 0.87 | KDR (0.54) | ABL1BRD4ATAD2JAK2JAK1 | |
| SCHEMBL25043278 | 0.87 | KDR (0.54) | ABL1BRD4ATAD2JAK2JAK1 | |
| SCHEMBL23332395 | 0.86 | CYP1A2 (0.45) | ABL1BRD4ATAD2JAK2JAK1 | |
| SCHEMBL30175699 | 0.86 | CYP1A2 (0.45) | ABL1BRD4ATAD2JAK2JAK1 | |
| SCHEMBL25044152 | 0.85 | JAK2 (0.47) | ABL1HRH3JAK2JAK1TYK2 | |
| SCHEMBL30175725 | 0.85 | JAK2 (0.47) | ABL1HRH3JAK2JAK1TYK2 | |
| SCHEMBL23301875 | 0.84 | BRD4 (0.43) | ABL1BRD4ATAD2MAPK14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230045929-A1 | ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230045929-A1 | ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS | SIK2, SIK3, SIK1 | ABL1 444/4885HRH3 843/4885BRD4 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.