Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.61 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.61 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.61 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.61 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.60 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.60 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.60 |
| ▸ | GAPDH | P04406 | 1/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31618014 | 1.00 | DOT1L (0.62) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL31617792 | 0.95 | DOT1L (0.69) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL25047821 | 0.95 | DOT1L (0.69) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL15395392 | 0.87 | EHMT1 (0.70) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL15984531 | 0.87 | EHMT1 (0.70) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL20097062 | 0.87 | EHMT1 (0.70) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL17568775 | 0.87 | EHMT1 (0.70) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL952831 | 0.86 | DOT1L (0.67) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL952828 | 0.86 | DOT1L (0.67) | DOT1LADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL28374784 | 0.85 | EHMT1 (0.74) | DOT1LADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017152-A1 | SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2023-02-16 | — | — | WO | disclosed |