Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 3/20 | 0.32 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | CDC7 | O00311 | 3/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.32 |
| ▸ | PIM1 | P11309 | 3/20 | 0.32 |
| ▸ | PRKACA | P17612 | 3/20 | 0.32 |
| ▸ | CLK2 | P49760 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.32 |
| ▸ | CDK7 | P50613 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | PRKX | P51817 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25048760 | 0.84 | RPS6KA5 (0.38) | RPS6KA5CDK8CDC7MAP4K4PIM1 | |
| SCHEMBL30941180 | 0.80 | KDM4E (0.44) | RPS6KA5JAK2CDC7PIM1PRKACA | |
| SCHEMBL30940969 | 0.77 | MAPT (0.44) | RPS6KA5JAK2CDK1MAP4K4CLK2 | |
| SCHEMBL30941505 | 0.74 | RPS6KA5 (0.36) | RPS6KA5JAK2CDC7MAP4K4PIM1 | |
| SCHEMBL31618036 | 0.64 | C1S (0.38) | RPS6KA5JAK2CDK1PIM1PRKACA | |
| SCHEMBL22518633 | 0.63 | RPS6KA5 (0.45) | RPS6KA5JAK2LRRK2DYRK1BAXL | |
| SCHEMBL25049125 | 0.63 | RPS6KA5 (0.41) | RPS6KA5ROCK1DYRK1BCDK2SYK | |
| SCHEMBL30941673 | 0.61 | RPS6KA5 (0.42) | RPS6KA5ROCK1DYRK1B | |
| SCHEMBL14842412 | 0.60 | AXL (0.47) | RPS6KA5PIM1CDK9DYRK1BAXL | |
| SCHEMBL18009669 | 0.60 | RPS6KA5 (0.40) | RPS6KA5DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017152-A1 | SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2023-02-16 | — | — | WO | disclosed |