Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | CCR3 | P51677 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | BID | P55957 | 1/20 | 0.32 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076204 | 0.97 | CRBN (0.40) | CRBNESR1HRH1CCR3KCNH2 | |
| SCHEMBL20046714 | 0.86 | CRBN (0.54) | CRBNESR1IKZF2IKZF1IKZF3 | |
| SCHEMBL20046717 | 0.83 | CRBN (0.54) | CRBNESR1IKZF2IKZF1IKZF3 | |
| SCHEMBL22645537 | 0.79 | IKZF2 (0.51) | CRBNESR1IKZF2IKZF1IKZF3 | |
| SCHEMBL22645533 | 0.79 | IKZF2 (0.51) | CRBNESR1IKZF2IKZF1IKZF3 | |
| SCHEMBL22692240 | 0.76 | CRBN (0.58) | CRBNESR1ARIKZF3 | |
| SCHEMBL22645559 | 0.76 | CRBN (0.58) | CRBNESR1IKZF2ARIKZF3 | |
| SCHEMBL22645556 | 0.76 | CRBN (0.58) | CRBNESR1IKZF2ARIKZF3 | |
| SCHEMBL23051804 | 0.74 | ESR1 (0.68) | CRBNESR1 | |
| SCHEMBL20046361 | 0.74 | CRBN (0.66) | CRBNESR1IKZF2ARIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |