Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rg-7603. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR known ✓ | P42345 | 20/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.75 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rg-7603 SCHEMBL1831522 | 1.00 | MTOR (1.00) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| Rg-7603 SCHEMBL1831520 | 1.00 | MTOR (1.00) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| Rg-7603 SCHEMBL29373340 | 1.00 | MTOR (1.00) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL2098645 | 0.95 | MTOR (0.91) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1830460 | 0.95 | MTOR (0.91) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1830931 | 0.95 | MTOR (0.91) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL2098648 | 0.95 | MTOR (0.91) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1832032 | 0.94 | MTOR (1.00) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1832036 | 0.94 | MTOR (1.00) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1832580 | 0.94 | MTOR (0.91) | MTORPIK3CACYP3A4KCNH2RPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230053946-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230053946-A1 | COMBINATIONS | CDK6, MTOR, CDK4 | MTOR 2/4885PIK3CA 19/4885CYP3A4 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.