Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 16/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | RPS27 | P42677 | 4/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2514883 | 0.88 | MAPK8 (0.49) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL1314174 | 0.84 | MAPK8 (0.60) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL2511759 | 0.82 | MAPK8 (0.46) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL1145397 | 0.78 | MAPK8 (0.59) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL2547184 | 0.76 | MAPK8 (0.42) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL1145423 | 0.76 | MAPK8 (0.59) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL1317582 | 0.74 | MAPK8 (0.57) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL1145807 | 0.73 | MAPK8 (0.56) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL12113069 | 0.73 | MAPK8 (0.56) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL13514301 | 0.73 | MAPK8 (0.70) | MAPK8MAPK9MAPK10PRKD3PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375899-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | Array Biopharma, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010080864-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2010-07-15 | — | — | WO | disclosed |