Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.47 |
| ▸ | INSR | P06213 | 7/20 | 0.47 |
| ▸ | NPM1 | P06748 | 6/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2507452 | 0.86 | JAK2 (0.72) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL520060 | 0.83 | JAK2 (0.83) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL519953 | 0.80 | JAK2 (0.71) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL520059 | 0.75 | JAK2 (0.64) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL520595 | 0.75 | JAK2 (0.70) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL520261 | 0.75 | JAK2 (1.00) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL16530494 | 0.72 | JAK2 (0.61) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL520290 | 0.72 | JAK2 (1.00) | JAK2ALKINSRNPM1CYP3A4 | |
| SCHEMBL520006 | 0.71 | JAK2 (0.59) | JAK2ALKINSRNPM1PTK2 | |
| SCHEMBL520483 | 0.71 | JAK2 (0.82) | JAK2ALKINSRNPM1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |