Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25075118 | 0.93 | NPC1 (0.41) | NPC1POLBHTTALDH1A1KMT2A | |
| SCHEMBL26494345 | 0.93 | NPC1 (0.41) | NPC1POLBHTTALDH1A1KMT2A | |
| SCHEMBL25075107 | 0.93 | NPC1 (0.41) | NPC1POLBHTTALDH1A1KMT2A | |
| SCHEMBL25075495 | 0.85 | NPC1 (0.42) | NPC1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL26494075 | 0.85 | NPC1 (0.44) | NPC1POLBHTTSMN1; SMN2GNAI3 | |
| SCHEMBL26496248 | 0.84 | HRH3 (0.40) | NPC1POLBHTTALDH1A1L3MBTL1 | |
| SCHEMBL26494149 | 0.84 | HRH3 (0.40) | NPC1POLBHTTALDH1A1L3MBTL1 | |
| SCHEMBL26494145 | 0.84 | NPC1 (0.46) | NPC1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL25075318 | 0.84 | NPC1 (0.46) | NPC1POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL26494350 | 0.84 | NPC1 (0.46) | NPC1POLBALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |