Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25480312 | 0.96 | SMN1; SMN2 (0.54) | SMN1; SMN2HSD11B1SIGMAR1HPGDPOLB | |
| SCHEMBL26494271 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2HSD11B1SIGMAR1HPGDPOLB | |
| SCHEMBL26295676 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2HSD11B1SIGMAR1HPGDALDH1A1 | |
| SCHEMBL25074969 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2HSD11B1SIGMAR1ALDH1A1ACKR3 | |
| SCHEMBL25074973 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2HSD11B1SIGMAR1HPGDPOLB | |
| SCHEMBL26494233 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2HSD11B1SIGMAR1HPGDPOLB | |
| SCHEMBL26494226 | 0.82 | HPGD (0.52) | SMN1; SMN2HSD11B1HPGDPOLBPKM | |
| SCHEMBL26494238 | 0.82 | HPGD (0.44) | SMN1; SMN2HSD11B1SIGMAR1HPGDPOLB | |
| SCHEMBL24334511 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2HSD11B1ALDH1A1HTTACKR3 | |
| SCHEMBL26263853 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2HSD11B1ALDH1A1HTTACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |