Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.80 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.80 |
| ▸ | PGR | P06401 | 2/20 | 0.80 |
| ▸ | SHBG | P04278 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.80 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.80 |
| ▸ | AR | P10275 | 1/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19327109 | 1.00 | HIF1A (1.00) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL139280 | 1.00 | HIF1A (1.00) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL13754708 | 1.00 | HIF1A (1.00) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL3940262 | 1.00 | HIF1A (1.00) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL139279 | 1.00 | HIF1A (1.00) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL14523057 | 1.00 | HIF1A (1.00) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL1626384 | 0.92 | HIF1A (0.84) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL1626382 | 0.92 | HIF1A (0.84) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL2484782 | 0.92 | HIF1A (0.84) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 | |
| SCHEMBL13147966 | 0.92 | HIF1A (0.84) | HIF1ALMNANR3C1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238545-B1 | C20 THROUGH C26 AMINO STEROIDS | UPJOHN CO (US) | 1995-11-15 | — | — | EP | claimed |
| EP-0054390-B1 | DEHALOGENATION OF STEROIDS | THE UPJOHN COMPANY (US) | 1984-07-25 | — | — | EP | claimed |
| US-4325881-A | Debromination | THE UPJOHN COMPANY (US) | 1982-04-20 | — | — | US | claimed |
| CN-118566493-A | Preparation method of blood reference product applied to next generation metabonomics | 上海阿趣生物科技有限公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-117126820-A | C11 alpha-hydroxylase mutant with improved catalytic activity, method and application thereof | 天津科技大学 | 2023-11-28 | — | — | CN | disclosed |
| CN-116593615-A | Method for detecting multiple endogenous steroid hormones in animal serum | 杭州师范大学 | 2023-08-15 | — | — | CN | disclosed |
| CN-106399342-B | Recombinant plasmid and recombinant engineering bacterium as well as construction method and application thereof | 天津大学 | 2019-12-31 | — | — | CN | disclosed |
| US-20140309186-A1 | Metabolomics-Based Identification of Disease-Causing Agents | GEORGIA TECH RESEARCH CORPORATION | 2014-10-16 | — | — | US | disclosed |
| US-20110246081-A1 | Metabolomics-Based Identification of Disease-Causing Agents | GEORGIA TECH RESEARCH CORPORATION (US) | 2011-10-06 | — | — | US | disclosed |
| EP-1976997-B1 | PROCESS FOR THE PREPARATION OF 11BETA-HYDR0XY-9BETA,10ALPHA-STEROIDS EMPLOYING AMYCOLATOPSIS MEDITERRANEI CELLS | SOLVAY PHARM GMBH (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-20080249075-A1 | C11 Modified Retrosteroids as Progesterone Receptor Modulator Compounds | SOLVAY PHARMACEUTICALS GMBH (DE) | 2008-10-09 | — | — | US | disclosed |
| US-4548748-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-10-22 | — | — | US | disclosed |
| US-4500461-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-02-19 | — | — | US | disclosed |
| EP-0003341-B1 | 11,17-SUBSTITUTED PREGNANES, THEIR PREPARATION AND APPLICATION FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-06-27 | — | — | EP | disclosed |
| US-4269778-A | REACTING AN ACETONE OR DIMETHYLFORMAMIDE SUSPENSION OF THE SULFONATE DERIVATIVE OBTAINED FROM REACTING THE ALCOHOL WITH A SULFONATING AGENT WITH A THIO CARBOXYLATE | SIPSY (FR) | 1981-05-26 | — | — | US | disclosed |
| US-4224320-A | Novel steroids of the pregnane series, substituted in the 17-position, their manufacture and their use | SCHERING, AKTIENGESELLSCHAFT (DE) | 1980-09-23 | — | — | US | disclosed |
| US-4207316-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-06-10 | — | — | US | disclosed |
| US-4013688-A | STEROIDS | THE UPJOHN COMPANY (US) | 1977-03-22 | — | — | US | disclosed |
| US-3984544-A | Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1976-10-05 | — | — | US | disclosed |
| US-3933799-A | HORMONES | GLAXO LABORATORIES LIMITED (EN) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249075-A1 | C11 Modified Retrosteroids as Progesterone Receptor Modulator Compounds | HSD17B11, CYP19A1, ESRRA | HIF1A 2433/4885LMNA 1111/4885NR3C1 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.