Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.50 |
| ▸ | INSR | P06213 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | NPM1 | P06748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519612 | 0.89 | JAK2 (0.66) | JAK2PTK2INSRALKNPM1 | |
| SCHEMBL520938 | 0.81 | JAK2 (0.66) | JAK2PTK2INSRALKNPM1 | |
| SCHEMBL520361 | 0.78 | JAK2 (0.80) | JAK2PTK2INSRALKNPM1 | |
| SCHEMBL520772 | 0.78 | JAK2 (0.44) | JAK2PTK2INSRALK | |
| SCHEMBL520999 | 0.78 | JAK2 (0.59) | JAK2PTK2INSRALK | |
| SCHEMBL2512061 | 0.78 | JAK2 (0.51) | JAK2PTK2INSRALK | |
| SCHEMBL521803 | 0.77 | JAK2 (0.76) | JAK2PTK2INSRALKNPM1 | |
| SCHEMBL521698 | 0.75 | JAK2 (0.63) | JAK2PTK2INSRALK | |
| SCHEMBL520689 | 0.74 | ALK (0.69) | JAK2PTK2INSRALKNPM1 | |
| SCHEMBL521664 | 0.74 | JAK2 (0.72) | JAK2PTK2INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |