Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521533 | 1.00 | JAK2 (1.00) | JAK2PTK2 | |
| SCHEMBL519853 | 0.94 | JAK2 (0.89) | JAK2PTK2 | |
| SCHEMBL519877 | 0.91 | JAK2 (0.83) | JAK2PTK2 | |
| SCHEMBL521389 | 0.91 | JAK2 (0.84) | JAK2PTK2 | |
| SCHEMBL520600 | 0.91 | JAK2 (1.00) | JAK2PTK2 | |
| SCHEMBL520072 | 0.90 | JAK2 (0.82) | JAK2PTK2 | |
| SCHEMBL520901 | 0.90 | JAK2 (0.82) | JAK2PTK2 | |
| SCHEMBL521618 | 0.89 | JAK2 (0.81) | JAK2PTK2 | |
| SCHEMBL521132 | 0.89 | JAK2 (0.81) | JAK2PTK2 | |
| SCHEMBL520179 | 0.89 | JAK2 (1.00) | JAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |