Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.71 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.49 |
| ▸ | INSR | P06213 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | BUB1B | O60566 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2525215 | 0.98 | JAK2 (0.70) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL520210 | 0.96 | JAK2 (0.77) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL521050 | 0.93 | JAK2 (0.76) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL522007 | 0.90 | JAK2 (0.78) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL2525216 | 0.89 | JAK2 (0.59) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL519462 | 0.83 | JAK2 (1.00) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL16530460 | 0.83 | JAK2 (0.72) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL521812 | 0.82 | JAK2 (0.67) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL520052 | 0.82 | JAK2 (0.72) | JAK2PTK2ALKINSRBRD4 | |
| SCHEMBL521291 | 0.82 | JAK2 (0.78) | JAK2PTK2ALKINSRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |