Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.49 |
| ▸ | IDH2 | P48735 | 17/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22591152 | 0.90 | IDH1 (0.58) | IDH1IDH2 | |
| SCHEMBL25100453 | 0.87 | IDH1 (0.63) | IDH1IDH2 | |
| SCHEMBL22591168 | 0.84 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL20289880 | 0.82 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL25100677 | 0.79 | IDH1 (0.72) | IDH1IDH2 | |
| SCHEMBL21799145 | 0.78 | IDH1 (0.75) | IDH1IDH2 | |
| SCHEMBL21799147 | 0.78 | IDH1 (0.75) | IDH1IDH2 | |
| SCHEMBL20289610 | 0.78 | IDH1 (0.75) | IDH1IDH2 | |
| SCHEMBL30341788 | 0.78 | IDH1 (0.75) | IDH1IDH2 | |
| SCHEMBL22591188 | 0.77 | IDH1 (0.81) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763717-B1 | PYRIDO[4,3-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | LILLY CO ELI (US) | 2023-03-08 | — | — | EP | disclosed |