Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 18/20 | 0.49 |
| ▸ | PLK1 | P53350 | 8/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25100626 | 1.00 | WEE1 (0.49) | WEE1PLK1BTKTNK2EGFR | |
| SCHEMBL25100639 | 1.00 | WEE1 (0.49) | WEE1PLK1BTKTNK2EGFR | |
| SCHEMBL25100694 | 0.95 | WEE1 (0.51) | WEE1PLK1BTKTNK2 | |
| SCHEMBL25100700 | 0.95 | WEE1 (0.51) | WEE1PLK1BTKTNK2 | |
| SCHEMBL25100695 | 0.95 | WEE1 (0.51) | WEE1PLK1BTKTNK2 | |
| SCHEMBL25100636 | 0.91 | WEE1 (0.53) | WEE1PLK1BTKEGFRCYP3A4 | |
| SCHEMBL25100611 | 0.91 | WEE1 (0.53) | WEE1PLK1BTKEGFRCYP3A4 | |
| SCHEMBL25100629 | 0.91 | WEE1 (0.53) | WEE1PLK1BTKEGFRCYP3A4 | |
| SCHEMBL25101102 | 0.91 | WEE1 (0.48) | WEE1PLK1BTKTNK2 | |
| SCHEMBL25101084 | 0.91 | WEE1 (0.48) | WEE1PLK1BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023030388-A1 | 5-FLUORO-7H-PYRROLO[2,3-D] PYRIMIDINES COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2023-03-09 | — | — | WO | disclosed |