Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 17/20 | 0.39 |
| ▸ | PLK1 | P53350 | 8/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26644462 | 1.00 | WEE1 (0.39) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL25100722 | 1.00 | WEE1 (0.39) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL30656352 | 0.89 | WEE1 (0.36) | WEE1PLK1 | |
| SCHEMBL25818945 | 0.89 | WEE1 (0.40) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL25818943 | 0.89 | WEE1 (0.40) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL26644607 | 0.89 | WEE1 (0.36) | WEE1PLK1 | |
| SCHEMBL26644601 | 0.89 | WEE1 (0.36) | WEE1PLK1 | |
| SCHEMBL25831324 | 0.86 | WEE1 (0.40) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL26644436 | 0.82 | WEE1 (0.36) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL25831530 | 0.79 | WEE1 (0.39) | WEE1PLK1EGFRCYP3A4MAP3K19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217201-A2 | NOVEL PYRIMIDO-HETEROCYCLIC NOVEL COMPOUND SERVING AS WEE1 INHIBITOR AND APPLICATION THEREOF | 杭州德睿智药科技有限公司 | 2023-11-16 | — | — | WO | disclosed |
| WO-2023125944-A1 | COMPOUND CONTAINING HETEROCYCLIC RING | 正大天晴药业集团股份有限公司 | 2023-07-06 | — | — | WO | disclosed |
| WO-2023030388-A1 | 5-FLUORO-7H-PYRROLO[2,3-D] PYRIMIDINES COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2023-03-09 | — | — | WO | disclosed |