Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23157600 | 1.00 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL20553600 | 1.00 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL25703384 | 0.94 | MTOR (0.67) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL24519462 | 0.94 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23157836 | 0.94 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23157965 | 0.94 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23251947 | 0.94 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23157795 | 0.94 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23157456 | 0.94 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23158078 | 0.94 | MTOR (0.69) | MTORHDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788049-B1 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-03-29 | — | — | EP | disclosed |