Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | PRKDC | P78527 | 3/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988089 | 0.92 | MTOR (0.60) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23251778 | 0.91 | MTOR (0.56) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23157523 | 0.91 | MTOR (0.55) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL29867644 | 0.91 | MTOR (0.55) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL21528059 | 0.91 | MTOR (0.55) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23251869 | 0.91 | MTOR (0.55) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23251935 | 0.91 | MTOR (0.55) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23251825 | 0.91 | MTOR (0.55) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23251924 | 0.90 | MTOR (0.58) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL24519483 | 0.90 | MTOR (0.61) | MTORHDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788049-B1 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-03-29 | — | — | EP | disclosed |