Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995877 | 0.79 | GAA (0.47) | MEN1KMT2ASMN1; SMN2GAAHTT | |
| SCHEMBL20862099 | 0.77 | MAPT (0.40) | HPGDMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12889181 | 0.76 | HPGD (0.45) | CYP1A2CYP2C9CYP2C19HPGDMEN1 | |
| SCHEMBL14549536 | 0.76 | HPGD (0.40) | CYP1A2CYP2C9CYP2C19HPGDMEN1 | |
| SCHEMBL26759422 | 0.73 | CYP1A2 (0.34) | CYP1A2CYP2C9CYP2C19HPGDMEN1 | |
| SCHEMBL23652392 | 0.73 | MEN1 (0.37) | CYP1A2CYP2C9CYP2C19HPGDMEN1 | |
| SCHEMBL19451888 | 0.72 | HPGD (0.40) | CYP1A2CYP2C9CYP2C19HPGDMEN1 | |
| SCHEMBL8293208 | 0.70 | MEN1 (0.35) | CYP1A2CYP2C9CYP2C19HPGDMEN1 | |
| SCHEMBL20440522 | 0.70 | FGFR4 (0.36) | MEN1KMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL14037701 | 0.69 | SRC (0.44) | CYP1A2CYP2C9CYP2C19HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4159736-A1 | NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Longwood Biopharmaceuticals Co., Ltd. (CN) | 2023-04-05 | — | — | EP | disclosed |