Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 1.00 |
| ▸ | HEXB | P07686 | 6/20 | 1.00 |
| ▸ | DHFR | P00374 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimethamine SCHEMBL29381161 | 1.00 | HEXA (1.00) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL15516970 | 1.00 | HEXA (1.00) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL28861797 | 0.98 | HEXA (0.97) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL28347069 | 0.98 | HEXA (0.97) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL11709944 | 0.98 | HEXA (0.97) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL8086889 | 0.98 | HEXA (0.97) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL27731084 | 0.91 | HEXA (0.83) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL30439479 | 0.90 | HEXA (0.81) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL21382838 | 0.90 | HEXA (0.81) | HEXAHEXBDHFRMEN1SLC22A1 | |
| Pyrimethamine SCHEMBL10747171 | 0.88 | HEXA (0.77) | HEXAHEXBDHFRMEN1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 21133 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| WO-2026086804-A1 | MULTILAYER-REGULATED GENE EDITING SYSTEM AND USE THEREOF | 自如基因科技（深圳）有限公司 | 2026-04-30 | — | — | WO | claimed |
| EP-4476936-B1 | USING MACHINE LEARNING MODELS TO GENERATE CONNECTIVITY GRAPHS BETWEEN DEVICE AND NETWORK NODES FOR USE IN CONDITIONAL HANDOVER PROCEDURES | ERICSSON TELEFON AB L M (SE) | 2026-04-29 | — | — | EP | claimed |
| EP-3790536-B1 | NANOCONTAINERS FOR TRANSPORTING NONPOLAR, LIPOPHILIC SUBSTANCES SUCH AS ANTIBIOTICS | KARLSRUHER INST TECHNOLOGIE (DE) | 2026-04-22 | — | — | EP | claimed |
| US-12600727-B2 | Treatment of infections of toxoplasma gondii and closely related parasites | WASHINGTON UNIVERSITY (US) | 2026-04-14 | — | — | US | claimed |
| US-20260097039-A1 | METHODS FOR TREATING A FATTY LIVER DISEASE | MADRIGAL PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | claimed |
| US-20260091119-A1 | ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA | CELLIS AG (CH) | 2026-04-02 | — | — | US | claimed |
| US-20260063633-A1 | Methods and Reagents for Toxoplasma Infection Diagnosis | MCLEOD RIMA (US) | 2026-03-05 | — | — | US | claimed |
| EP-4702057-A1 | IN VIVO IMAGING OF AN ALS BIOMARKER AND MEANS THEREFOR | AL-S Pharma AG (CH) | 2026-03-04 | — | — | EP | claimed |
| EP-4695070-A1 | DEVICE AND METHOD FOR PRODUCING A FILM FOR ELECTRICAL ENERGY STORAGE SYSTEMS | Coperion GmbH (DE) | 2026-02-18 | — | — | EP | claimed |
| US-4599416-A | Process for the preparation of aqueous solutions of potentiated sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1986-07-08 | — | — | US | claimed |
| US-4579855-A | MODIFICATION E; ANTIMALARIAL | HOFFMANN-LA ROCHE INC. (US) | 1986-04-01 | — | — | US | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4474751-A | SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |
| EP-0076636-A1 | Sustained release compositions | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1983-04-13 | — | — | EP | claimed |
| EP-0000291-B1 | A PHARMACEUTICAL COMPOSITION FOR TROPICAL DISEASES | University of Strathclyde (GB) | 1981-09-30 | — | — | EP | claimed |
| EP-0001796-B1 | ANTI-MALARIA DRUG | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-06-10 | — | — | EP | claimed |
| US-4221779-A | MALARIA | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1980-09-09 | — | — | US | claimed |
| EP-0001796-A1 | Anti-malaria drug | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-16 | — | — | EP | claimed |
| US-4062940-A | Water-soluble composition comprising sulfadimidine and pyrimethamine | ABIC LTD. (IL) | 1977-12-13 | — | — | US | claimed |