L-Homocysteine

L-Homocysteine

SCHEMBL2513063

N[C@@H](CCS)C(=O)O.O=C(O)O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of L-Homocysteine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.59
SLC7A11 Q9UPY5 1/20 0.59
GSR P00390 2/20 0.54
GRM8 O00222 1/20 0.54
GRM6 O15303 1/20 0.54
GRIN2D O15399 1/20 0.54
GRIN3B O60391 1/20 0.54
CYP1A2 P05177 1/20 0.54
GRIK1 P39086 1/20 0.54
GRM5 P41594 1/20 0.54
GRIA1 P42261 1/20 0.54
GRIA2 P42262 1/20 0.54
GRIA3 P42263 1/20 0.54
SLC1A3 P43003 1/20 0.54
SLC1A2 P43004 1/20 0.54
SLC1A1 P43005 1/20 0.54
GRIA4 P48058 1/20 0.54
GRIN1 Q05586 1/20 0.54
GRIN2A Q12879 1/20 0.54
GRIK2 Q13002 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Homocysteine SCHEMBL2513065 1.00 PTGS1 (0.59) PTGS1SLC7A11GSRGRM8GRM6
Homocysteine SCHEMBL28927454 0.97 PTGS1 (0.62) PTGS1SLC7A11GSRGRM8GRM6
Homocysteine SCHEMBL35836 0.97
Homocysteine SCHEMBL936365 0.97 PTGS1 (0.62) PTGS1SLC7A11GSRGRM8GRM6
Homocysteine SCHEMBL601148 0.97
L-Homocysteine SCHEMBL35837 0.97
L-Homocysteine SCHEMBL936366 0.97 PTGS1 (0.62) PTGS1SLC7A11GSRGRM8GRM6
L-Homocysteine SCHEMBL23721811 0.95 PTGS1 (0.59) PTGS1SLC7A11GSRGRM8GRM6
Homocysteine SCHEMBL3326967 0.95
Homocysteine SCHEMBL3077444 0.95

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190119708-A1 METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS OPX BIOTECHNOLOGIES, INC. 2019-04-25 US disclosed
US-10100342-B2 Method for producing 3-hydroxypropionic acid and other products CARGILL, INCORPORATED (US) 2018-10-16 US disclosed
EP-2480673-B1 METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS OPX BIOTECHNOLOGIES INC (US) 2018-05-23 EP disclosed
US-20170114377-A1 METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS OPX BIOTECHNOLOGIES, INC. 2017-04-27 US disclosed
US-9428778-B2 Method for producing 3-hydroxypropionic acid and other products CARGILL, INCORPORATED (US) 2016-08-30 US disclosed
US-9388419-B2 Methods for producing 3-hydroxypropionic acid and other products CARGILL, INCORPORATED (US) 2016-07-12 US disclosed
US-20150344916-A1 METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS OPX BIOTECHNOLOGIES, INC. 2015-12-03 US disclosed
US-20150056651-A1 MICROORGANISM PRODUCTION OF HIGH-VALUE CHEMICAL PRODUCTS, AND RELATED COMPOSITIONS, METHODS AND SYSTEMS OPX BIOTECHNOLOGIES INC (US) 2015-02-26 US disclosed
US-20150056684-A1 METHODS, SYSTEMS, AND COMPOSITIONS FOR INCREASED MICROORGANISM TOLERANCE TO AND PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 2015-02-26 US disclosed
US-8883464-B2 Methods for producing 3-hydroxypropionic acid and other products OPX BIOTECHNOLOGIES, INC. (US) 2014-11-11 US disclosed
US-20140045231-A1 METHODS FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 2014-02-13 US disclosed
US-20130122541-A1 MICROORGANISM PRODUCTION OF HIGH-VALUE CHEMICAL PRODUCTS, AND RELATED COMPOSITIONS, METHODS AND SYSTEMS THE REGENTS OF THE UNIVERSITY OF COLORADO 2013-05-16 US disclosed
US-20130071893-A1 METHODS FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS OPX BIOTECHNOLOGIES, INC. (US) 2013-03-21 US disclosed
US-20120264902-A1 Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP) THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2012-10-18 US disclosed
US-20110244575-A1 METHODS, SYSTEMS AND COMPOSITIONS FOR INCREASED MICROORGANISM TOLERANCE TO AND PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) OPX BIOTECHNOLOGIES, INC. 2011-10-06 US disclosed