Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 4/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521430 | 0.95 | JAK2 (0.60) | JAK2PTK2INSRALKNUAK1 | |
| SCHEMBL521616 | 0.82 | JAK2 (0.57) | JAK2PTK2INSRALKCRBN | |
| SCHEMBL519827 | 0.80 | JAK2 (0.56) | JAK2PTK2INSRALKCYP3A4 | |
| SCHEMBL520120 | 0.80 | JAK2 (0.61) | JAK2PTK2INSRALKCYP3A4 | |
| SCHEMBL16530525 | 0.78 | JAK2 (0.51) | JAK2PTK2INSRALKCRBN | |
| SCHEMBL531103 | 0.76 | JAK2 (0.73) | JAK2PTK2INSRALKCYP3A4 | |
| SCHEMBL520953 | 0.76 | JAK2 (0.73) | JAK2PTK2INSRALKCYP3A4 | |
| SCHEMBL521759 | 0.76 | JAK2 (0.59) | JAK2PTK2INSRALKCYP3A4 | |
| SCHEMBL520799 | 0.75 | JAK2 (0.71) | JAK2PTK2INSRALKCYP3A4 | |
| SCHEMBL521246 | 0.75 | JAK2 (0.52) | JAK2PTK2INSRALKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |