SCHEMBL2513754 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	18/20	0.48

▸	FGR	P09769	1/20	0.37

▸	SRC	P12931	1/20	0.37

▸	TEC	P42680	1/20	0.37

▸	BMX	P51813	1/20	0.37

▸	TP53	P04637	1/20	0.32

▸	MAPT	P10636	1/20	0.32

▸	WDR5	P61964	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2462198	0.86	BTK (0.48)	BTKFGRSRCTECBMX
SCHEMBL2468853	0.86	BTK (0.48)	BTKFGRSRCTECBMX
SCHEMBL9984459	0.86	BTK (0.48)	BTKFGRSRCTECBMX
SCHEMBL2462193	0.86	BTK (0.48)	BTKFGRSRCTECBMX
SCHEMBL9985028	0.86	BTK (0.48)	BTKFGRSRCTECBMX
SCHEMBL2462328	0.86	BTK (0.48)	BTKFGRSRCTECBMX
SCHEMBL9984873	0.86	BTK (0.48)	BTKFGRSRCTECBMX
SCHEMBL2511060	0.85	BTK (0.49)	BTKFGRSRCTECBMX
SCHEMBL2490972	0.84	BTK (0.53)	BTKFGRSRCTECBMX
SCHEMBL2464208	0.82	BTK (0.46)	BTKFGRSRCTECBMX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2365970-A1	Pyridazinones and their use as btk inhibitors	CGI Pharmaceuticals, Inc. (US)	2011-09-21	—	—	EP	disclosed
WO-2010056875-A1	PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS	CGI PHARMACEUTICALS, INC. (US)	2010-05-20	—	—	WO	disclosed