Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 11/20 | 0.37 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346312 | 0.88 | TSHR (0.44) | TSHRTHRBFDPSGGPS1SMPD1 | |
| SCHEMBL20419697 | 0.82 | TSHR (0.44) | TSHRTHRBFDPSGGPS1SMPD1 | |
| SCHEMBL13192531 | 0.82 | TSHR (0.44) | TSHRTHRBFDPSGGPS1SMPD1 | |
| SCHEMBL11928326 | 0.77 | TSHR (0.44) | TSHRTHRBFDPSGGPS1SMPD1 | |
| SCHEMBL12946311 | 0.77 | TSHR (0.44) | TSHRTHRBFDPSGGPS1SMPD1 | |
| SCHEMBL19865511 | 0.75 | — | — | |
| SCHEMBL26876446 | 0.75 | TSHR (0.50) | TSHRTHRBFDPSGGPS1SMPD1 | |
| SCHEMBL9633323 | 0.73 | TSHR (0.47) | TSHRTHRBFDPSGGPS1LMNA | |
| SCHEMBL18611378 | 0.73 | TSHR (0.47) | TSHRTHRBFDPSGGPS1SMPD1 | |
| SCHEMBL13192915 | 0.73 | TSHR (0.47) | TSHRTHRBFDPSGGPS1SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062049-A1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-04-20 | — | — | WO | disclosed |