Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30332059 | 1.00 | MAPT (0.49) | MAPTNR1H2ESR2HPGDSMAPK1 | |
| SCHEMBL10313002 | 0.87 | MAPT (0.52) | MAPTNR1H2ESR2HPGDSMAPK1 | |
| SCHEMBL10313009 | 0.87 | MAPT (0.52) | MAPTNR1H2ESR2HPGDSMAPK1 | |
| SCHEMBL13226354 | 0.83 | MAPT (0.48) | MAPTNR1H2ESR2HPGDSMAPK1 | |
| SCHEMBL2211825 | 0.83 | MAPT (0.52) | MAPTNR1H2ESR2 | |
| SCHEMBL29507818 | 0.82 | NR1H2 (0.64) | MAPTNR1H2ESR2HPGDSMAPK1 | |
| SCHEMBL3002453 | 0.82 | NR1H2 (0.64) | MAPTNR1H2ESR2HPGDSMAPK1 | |
| SCHEMBL29421798 | 0.82 | ESR2 (0.47) | MAPTNR1H2ESR2GPR119 | |
| SCHEMBL13226239 | 0.81 | ESR2 (0.63) | MAPTNR1H2ESR2HPGDSMAPK1 | |
| SCHEMBL25153126 | 0.81 | MAPT (0.55) | MAPTNR1H2ESR2HPGDSMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064585-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | VANDERBILT UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |