Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25147660 | 0.78 | HSP90AA1 (0.52) | HSP90AA1SMN1; SMN2RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL16415975 | 0.71 | SLC6A2 (0.45) | SLC6A2HTR1A | |
| SCHEMBL9371356 | 0.70 | HSP90AA1 (0.54) | HSP90AA1SMN1; SMN2KDM4ERAB9AALDH1A1 | |
| SCHEMBL17156499 | 0.70 | HRH4 (0.50) | HSP90AA1SMN1; SMN2KDM4ERAB9AALDH1A1 | |
| SCHEMBL870736 | 0.70 | HSP90AA1 (0.54) | HSP90AA1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL5939965 | 0.69 | HSP90AA1 (0.53) | HSP90AA1SMN1; SMN2RAB9AALDH1A1MEN1 | |
| SCHEMBL11040381 | 0.69 | HSP90AA1 (0.53) | HSP90AA1SMN1; SMN2KDM4ERAB9AALDH1A1 | |
| SCHEMBL22534769 | 0.68 | MEN1 (0.45) | HSP90AA1KDM4EMEN1KMT2ASLC6A2 | |
| SCHEMBL18173902 | 0.67 | HSP90AA1 (0.47) | HSP90AA1SMN1; SMN2KDM4ERAB9ANPSR1 | |
| SCHEMBL28442014 | 0.66 | HSP90AA1 (0.49) | HSP90AA1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250034112-A1 | IMPROVED SELECTIVE JAK2 INHIBITORS AND METHODS OF USE | UNIV YALE (US) | 2025-01-30 | — | — | US | disclosed |
| WO-2023064458-A1 | SELECTIVE JAK2 INHIBITORS AND METHODS OF USE | YALE UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2023064458-A1 | SELECTIVE JAK2 INHIBITORS AND METHODS OF USE | YALE UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250034112-A1 | IMPROVED SELECTIVE JAK2 INHIBITORS AND METHODS OF USE | JAK2, JAK1, MCL1 | HSP90AA1 1488/4885SMN1; SMN2 3674/4885KDM4E 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.