Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.64 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.64 |
| ▸ | MAP3K11 | Q16584 | 17/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.60 |
| ▸ | SGK1 | O00141 | 1/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | CHUK | O15111 | 1/20 | 0.60 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31396549 | 1.00 | DYRK1A (0.64) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 | |
| SCHEMBL29253587 | 0.87 | MAP3K11 (0.75) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 | |
| SCHEMBL30938065 | 0.87 | MAP3K11 (0.75) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 | |
| SCHEMBL25153308 | 0.86 | MAP3K11 (0.81) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 | |
| SCHEMBL31396599 | 0.86 | MAP3K11 (0.81) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 | |
| SCHEMBL31396600 | 0.82 | MAP4K1 (0.59) | DYRK1ADYRK2DYRK1BMAP3K11CLK1 | |
| SCHEMBL25153309 | 0.82 | MAP4K1 (0.59) | DYRK1ADYRK2DYRK1BMAP3K11CLK1 | |
| SCHEMBL25153604 | 0.81 | DYRK1A (0.40) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 | |
| SCHEMBL723789 | 0.79 | MAP3K11 (1.00) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 | |
| SCHEMBL12763475 | 0.79 | MAP3K11 (0.83) | DYRK1ADYRK2DYRK1BMAP3K11CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064218-A1 | TYRO3 INHIBITORS | Halia Therapeutics, Inc. (US) | 2023-04-20 | — | — | WO | disclosed |