Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | CDK7 | P50613 | 4/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25522919 | 1.00 | BRD4 (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL25522921 | 1.00 | BRD4 (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL30406605 | 1.00 | BRD4 (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL25522665 | 0.91 | DYRK1A (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL30407345 | 0.91 | DYRK1A (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL25519916 | 0.87 | BRD4 (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL30346467 | 0.87 | BRD4 (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL30348752 | 0.87 | DYRK1A (0.51) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL25157004 | 0.87 | DYRK1A (0.51) | BRD4DYRK1ACLK2CLK3DYRK1B | |
| SCHEMBL30406830 | 0.87 | BRD4 (0.41) | BRD4DYRK1ACLK2CLK3DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |