Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389086 | 0.86 | NAMPT (0.55) | NAMPTSPRALDH1A1MKNK1MKNK2 | |
| SCHEMBL2392435 | 0.83 | NAMPT (0.54) | NAMPTSPRKDM4EALDH1A1APLNR | |
| SCHEMBL15732482 | 0.83 | NAMPT (0.56) | NAMPTSPRHSD11B1 | |
| SCHEMBL2391652 | 0.81 | NAMPT (0.53) | NAMPTSPRHSD11B1 | |
| SCHEMBL2391643 | 0.81 | NAMPT (0.51) | NAMPTSPRAPLNRHSD11B1ROCK2 | |
| SCHEMBL2388338 | 0.81 | NAMPT (0.52) | NAMPTSPRKDM4EALDH1A1HSD11B1 | |
| SCHEMBL2390891 | 0.80 | NAMPT (0.53) | NAMPTSPRKDM4EALDH1A1APLNR | |
| SCHEMBL2389382 | 0.76 | NAMPT (0.57) | NAMPTSPRALDH1A1APLNRHSD11B1 | |
| SCHEMBL2388732 | 0.75 | NAMPT (0.52) | NAMPTSPRKDM4EALDH1A1APLNR | |
| SCHEMBL12255562 | 0.75 | NAMPT (0.60) | NAMPTSPRALDH1A1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375904-A1 | BIARYL CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010077624-A1 | BIARYL CARBOXAMIDES | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | disclosed |