Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | TXK | P42681 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14633944 | 0.90 | BTK (0.45) | EPHB4BTKLYNTXKSYK | |
| Trifluoroacetic Acid SCHEMBL14634337 | 0.84 | AURKA (0.41) | EPHB4BTKLYNTXKSYK | |
| SCHEMBL14633980 | 0.82 | BTK (0.43) | EPHB4BTKLYNTXKSYK | |
| Trifluoroacetic Acid SCHEMBL14634212 | 0.81 | GRM4 (0.43) | EPHB4KDRCDK4CCNE1CDK2 | |
| SCHEMBL14634153 | 0.81 | IGF1R (0.45) | EPHB4KDRBRD4MEN1NPC1 | |
| SCHEMBL2516608 | 0.81 | RIPK2 (0.42) | EPHB4BTKLYNTXKSYK | |
| SCHEMBL14634221 | 0.80 | RIPK2 (0.49) | EPHB4BTKLYNTXKSYK | |
| SCHEMBL14634053 | 0.79 | KDR (0.44) | EPHB4BTKLYNTXKSYK | |
| SCHEMBL2517604 | 0.78 | RIPK2 (0.41) | EPHB4BTKLYNTXKSYK | |
| SCHEMBL14634174 | 0.78 | RIPK2 (0.49) | EPHB4BTKLYNTXKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552211-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |