Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 13/20 | 0.37 |
| ▸ | EHMT1 | Q9H9B1 | 12/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25166036 | 1.00 | EHMT2 (0.37) | EHMT2EHMT1IGF1RALDH1A1TP53 | |
| SCHEMBL30329927 | 1.00 | EHMT2 (0.37) | EHMT2EHMT1IGF1RALDH1A1TP53 | |
| SCHEMBL25166545 | 1.00 | EHMT2 (0.37) | EHMT2EHMT1IGF1RALDH1A1TP53 | |
| SCHEMBL25165934 | 0.85 | EHMT2 (0.41) | EHMT2EHMT1IGF1RALDH1A1TP53 | |
| SCHEMBL30329814 | 0.85 | EHMT2 (0.41) | EHMT2EHMT1IGF1RALDH1A1TP53 | |
| SCHEMBL30329672 | 0.82 | EHMT2 (0.42) | EHMT2EHMT1IGF1RALDH1A1MAPT | |
| SCHEMBL25166033 | 0.82 | EHMT2 (0.42) | EHMT2EHMT1IGF1RALDH1A1MAPT | |
| SCHEMBL25166264 | 0.82 | EHMT2 (0.42) | EHMT2EHMT1IGF1R | |
| SCHEMBL25166025 | 0.82 | EHMT2 (0.42) | EHMT2EHMT1IGF1R | |
| SCHEMBL30329775 | 0.82 | EHMT2 (0.42) | EHMT2EHMT1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064586-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |