Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 13/20 | 0.63 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25176627 | 0.92 | SPHK2 (0.72) | SPHK2SPHK1 | |
| SCHEMBL25177129 | 0.91 | SPHK2 (0.75) | SPHK2SPHK1 | |
| SCHEMBL25171124 | 0.89 | SPHK2 (0.74) | SPHK2SPHK1EPHB4TEKKDR | |
| SCHEMBL29308069 | 0.88 | SPHK2 (0.70) | SPHK2SPHK1EPHB4TEK | |
| SCHEMBL25171094 | 0.88 | SPHK2 (0.75) | SPHK2SPHK1 | |
| SCHEMBL25171095 | 0.88 | SPHK2 (0.58) | SPHK2SPHK1 | |
| SCHEMBL25176673 | 0.87 | SPHK2 (0.54) | SPHK2SPHK1EPHB4TEK | |
| SCHEMBL25176674 | 0.87 | SPHK2 (0.54) | SPHK2SPHK1EPHB4TEK | |
| SCHEMBL25176646 | 0.86 | SPHK2 (0.73) | SPHK2SPHK1 | |
| SCHEMBL25447470 | 0.86 | SPHK2 (0.81) | SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037329-B2 | SphK inhibitors and methods of making and using same | WASHINGTON UNIVERSITY (US) | 2024-07-16 | — | — | US | disclosed |
| US-20230150990-A1 | SPHK INHIBITORS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12037329-B2 | SphK inhibitors and methods of making and using same | SPHK2, SPHK1, CLK2 | SPHK2 1/4885SPHK1 2/4885EPHB4 4539/4885 |
| US-20230150990-A1 | SPHK INHIBITORS AND METHODS OF MAKING AND USING SAME | SPHK2, SPHK1, CLK2 | SPHK2 1/4885SPHK1 2/4885EPHB4 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.