Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.40 |
| ▸ | MAOB | P27338 | 5/20 | 0.40 |
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602776 | 0.92 | HRH4 (0.44) | MAOAMAOBBCHEACHEHRH4 | |
| SCHEMBL602774 | 0.91 | HRH4 (0.46) | MAOAMAOBBCHEACHEHRH4 | |
| SCHEMBL602507 | 0.86 | HRH4 (0.38) | HRH4HRH3MET | |
| SCHEMBL604488 | 0.86 | JAK2 (0.41) | HRH4HRH3ADORA1ADORA2AROCK1 | |
| SCHEMBL605671 | 0.81 | HRH4 (0.42) | BCHEACHEHRH4HRH3DRD3 | |
| SCHEMBL605373 | 0.80 | HRH4 (0.39) | HRH4HRH3MET | |
| SCHEMBL2165213 | 0.80 | EP300 (0.42) | MAOBHRH4 | |
| SCHEMBL601537 | 0.79 | HRH4 (0.60) | HRH4HRH3ADORA1ADORA2AADORA2B | |
| SCHEMBL605187 | 0.79 | HRH4 (0.44) | HRH4HRH3MET | |
| SCHEMBL604458 | 0.76 | HRH4 (0.42) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039498-B2 | Imidazole compounds | JANSSEN PHARMACEUTICA NV (BE) | 2011-10-18 | — | — | US | disclosed |
| US-20070265250-A1 | Imidazole compounds | BUZARD DANIEL J | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265250-A1 | Imidazole compounds | HRH4, HRH3, HRH2 | MAOA 2584/4885MAOB 2041/4885BCHE 3177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.