Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.58 |
| ▸ | FGR | P09769 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | TEC | P42680 | 1/20 | 0.44 |
| ▸ | BMX | P51813 | 1/20 | 0.44 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461953 | 0.86 | BTK (0.66) | BTKFGRSRCTECBMX | |
| SCHEMBL2467544 | 0.85 | BTK (0.62) | BTKFGRSRCTECBMX | |
| SCHEMBL2461862 | 0.84 | BTK (0.67) | BTKFGRSRCTECBMX | |
| SCHEMBL2491555 | 0.83 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2462150 | 0.83 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2462161 | 0.82 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL2463870 | 0.80 | BTK (0.61) | BTKFGRSRCTECBMX | |
| SCHEMBL2491712 | 0.80 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL2527943 | 0.80 | BTK (0.61) | BTKFGRSRCTECBMX | |
| SCHEMBL9986674 | 0.80 | BTK (0.62) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-A1 | Pyridazinones and their use as btk inhibitors | CGI Pharmaceuticals, Inc. (US) | 2011-09-21 | — | — | EP | claimed |
| WO-2010056875-A1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | claimed |