Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30325623 | 1.00 | MEN1 (0.39) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL2301080 | 1.00 | MEN1 (0.39) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL21335536 | 1.00 | MEN1 (0.39) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL26607392 | 1.00 | MEN1 (0.39) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL2670204 | 0.86 | MEN1 (0.35) | MEN1MAPK1KMT2AGAABTK | |
| SCHEMBL4748874 | 0.86 | MEN1 (0.37) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL2670376 | 0.86 | MEN1 (0.37) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL4918795 | 0.85 | MEN1 (0.38) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL2670103 | 0.85 | MEN1 (0.38) | MEN1MAPK1KMT2AGAAEPHX2 | |
| SCHEMBL7517321 | 0.85 | PSEN1 (0.35) | MEN1MAPK1KMT2AGAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091456-A1 | N-(2H-INDAZOL-5-YL)PYRAZINE-2-CARBOXAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS HTT MODULATORS FOR THE TREATMENT OF HUNTINGTON'S DISEASE | CHDI FOUNDATION, INC. (US) | 2023-05-25 | — | — | WO | disclosed |