Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 17/20 | 0.57 |
| ▸ | EGFR | P00533 | 16/20 | 0.57 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520501 | 0.97 | ERBB2 (0.57) | ERBB2EGFRERBB3ERBB4GRM4 | |
| SCHEMBL2544657 | 0.92 | ERBB2 (0.62) | ERBB2EGFRERBB3ERBB4AURKA | |
| SCHEMBL2544330 | 0.91 | ERBB2 (0.69) | ERBB2EGFRERBB3ERBB4GRM4 | |
| SCHEMBL2544378 | 0.91 | EGFR (0.51) | ERBB2EGFRERBB3ERBB4GRM4 | |
| SCHEMBL5531018 | 0.89 | ERBB2 (0.59) | ERBB2EGFRERBB3ERBB4AURKA | |
| SCHEMBL2542968 | 0.88 | EGFR (0.71) | ERBB2EGFRKCNH2 | |
| SCHEMBL5520007 | 0.87 | EGFR (0.65) | ERBB2EGFRKCNH2 | |
| SCHEMBL2535974 | 0.87 | EGFR (0.71) | ERBB2EGFRKCNH2 | |
| SCHEMBL2520860 | 0.87 | ERBB2 (0.57) | ERBB2EGFRKCNH2 | |
| SCHEMBL5518435 | 0.87 | EGFR (0.71) | ERBB2EGFRERBB3ERBB4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838712-B8 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2011-10-12 | — | — | EP | disclosed |
| EP-1838712-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006064196-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |