Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.56 |
| ▸ | JAK2 | O60674 | 4/20 | 0.56 |
| ▸ | TYK2 | P29597 | 4/20 | 0.56 |
| ▸ | JAK1 | P23458 | 4/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.56 |
| ▸ | FLT3 | P36888 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | BTK | Q06187 | 3/20 | 0.56 |
| ▸ | PLK4 | O00444 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.56 |
| ▸ | MST1R | Q04912 | 3/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2526118 | 0.91 | SYK (0.61) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2521050 | 0.89 | SYK (0.57) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2526665 | 0.88 | SYK (0.56) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2518417 | 0.85 | SYK (0.63) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2516431 | 0.84 | SYK (0.62) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2521971 | 0.84 | SYK (0.60) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2526159 | 0.82 | SYK (0.72) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL12854457 | 0.81 | JAK3 (0.51) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2525986 | 0.81 | SYK (0.61) | SYKJAK3JAK2TYK2JAK1 | |
| SCHEMBL2525992 | 0.80 | SYK (0.64) | SYKJAK3JAK2TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618095-B2 | 2, 4-pyrimidinediamine compounds and prodrugs thereof and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2013-12-31 | — | — | US | claimed |
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | US | claimed |
| EP-2558474-B1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-11-25 | — | — | EP | disclosed |
| EP-2558474-B1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-11-25 | — | — | EP | disclosed |
| US-8618095-B2 | 2, 4-pyrimidinediamine compounds and prodrugs thereof and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | US | disclosed |
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | US | disclosed |
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251177-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | TYMP, DPYD, TYMS | SYK 1871/4885JAK3 2636/4885JAK2 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.