Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.69 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833176 | 1.00 | PRMT5 (0.69) | PRMT5WDR77USP2PARP1MEN1 | |
| SCHEMBL29735224 | 0.81 | PRMT5 (0.90) | PRMT5WDR77PARP1GRM5TYR | |
| SCHEMBL23087341 | 0.81 | PRMT5 (0.90) | PRMT5WDR77PARP1GRM5TYR | |
| SCHEMBL23087458 | 0.81 | PRMT5 (1.00) | PRMT5WDR77PARP1GRM5RAB9A | |
| SCHEMBL30431001 | 0.80 | PRMT5 (0.44) | PRMT5WDR77PARP1ALDH1A1DYRK1B | |
| SCHEMBL23087447 | 0.79 | PRMT5 (0.69) | PRMT5WDR77PARP1MEN1KMT2A | |
| SCHEMBL29735278 | 0.79 | PRMT5 (0.69) | PRMT5WDR77PARP1MEN1KMT2A | |
| SCHEMBL23087513 | 0.78 | PRMT5 (0.67) | PRMT5WDR77PARP1MAPTCYP1B1 | |
| SCHEMBL29735135 | 0.78 | PRMT5 (0.67) | PRMT5WDR77PARP1MAPTCYP1B1 | |
| SCHEMBL23099038 | 0.76 | PRMT5 (0.73) | PRMT5WDR77PARP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117730075-A | Pyrazole derivative, preparation method and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| WO-2023098439-A1 | PYRAZOLE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 上海和誉生物医药科技有限公司 | 2023-06-08 | — | — | WO | disclosed |
| WO-2023098439-A1 | PYRAZOLE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 上海和誉生物医药科技有限公司 | 2023-06-08 | — | — | WO | disclosed |