Sugi Predict

Sugi Predict / Compounds / SCHEMBL25214908

SCHEMBL25214908

SCHEMBL25214908

Cc1ccc(S(=N)(=O)c2ccc(C(=O)Nc3cc(-c4ccc(F)cc4)ccc3NC(=O)OC(C)(C)C)cc2)cn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP17A1 P05093 1/20 0.42
▸ HDAC1 Q13547 3/20 0.40
▸ RORC P51449 3/20 0.38
▸ MMP8 P22894 2/20 0.38
▸ MMP3 P08254 1/20 0.38
▸ KCNQ4 P56696 1/20 0.38
▸ KCNQ5 Q9NR82 1/20 0.38
▸ MCHR1 Q99705 2/20 0.37
▸ HDAC2 Q92769 2/20 0.37
▸ KCNQ3 O43525 1/20 0.37
▸ KCNQ2 O43526 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ AAK1 Q2M2I8 1/20 0.37
▸ NAMPT P43490 1/20 0.37
▸ HDAC3 O15379 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30474691 1.00 CYP17A1 (0.42) CYP17A1HDAC1RORCMMP8MMP3
SCHEMBL25251162 0.93 CYP17A1 (0.42) CYP17A1HDAC1RORCMMP8MMP3
SCHEMBL25214971 0.92 CYP17A1 (0.46) CYP17A1HDAC1RORCMMP8MMP3
SCHEMBL25210854 0.91 CYP17A1 (0.42) CYP17A1HDAC1RORCMMP8MMP3
SCHEMBL30474773 0.91 CYP17A1 (0.42) CYP17A1HDAC1RORCMMP8MMP3
SCHEMBL25249247 0.91 KCNQ3 (0.45) CYP17A1HDAC1RORCKCNQ4KCNQ5
SCHEMBL25242870 0.91 CYP17A1 (0.42) CYP17A1HDAC1RORCMMP8MMP3
SCHEMBL25255018 0.90 HDAC1 (0.46) CYP17A1HDAC1KMT2AAAK1NAMPT
SCHEMBL30474840 0.90 HDAC1 (0.46) CYP17A1HDAC1KMT2AAAK1NAMPT
SCHEMBL25252847 0.90 CYP17A1 (0.41) CYP17A1HDAC1RORCKCNQ4KCNQ5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250136570-A1 HDAC INHIBITORS AND THERAPEUTIC USE THEREOF TANGO THERAPEUTICS, INC. 2025-05-01 — — US disclosed
US-12043607-B2 HDAC inhibitors and therapeutic use thereof TANGO THERAPEUTICS, INC. (US) 2024-07-23 — — US disclosed
US-12043607-B2 HDAC inhibitors and therapeutic use thereof TANGO THERAPEUTICS, INC. (US) 2024-07-23 — — US disclosed
WO-2023102162-A1 TGONOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF TANGO THERAPEUTICS, INC. (US) 2023-06-08 — — WO disclosed
US-20230174501-A1 NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF TANGO THERAPEUTICS, INC. 2023-06-08 — — US disclosed
US-20230174501-A1 NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF TANGO THERAPEUTICS, INC. 2023-06-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174501-A1 NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF HDAC1, HDAC7, HDAC5 CYP17A1 1294/4885HDAC1 1/4885RORC 663/4885
US-20250136570-A1 HDAC INHIBITORS AND THERAPEUTIC USE THEREOF HDAC1, HDAC7, HDAC5 CYP17A1 657/4885HDAC1 1/4885RORC 699/4885
US-12043607-B2 HDAC inhibitors and therapeutic use thereof HDAC1, HDAC7, HDAC5 CYP17A1 657/4885HDAC1 1/4885RORC 699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.