SCHEMBL25224327

SCHEMBL25224327

CNC(Cc1ccc2c(c1)OCO2)c1ccccc1

nearest known ligand 0.97

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.62
SLC6A4 P31645 3/20 0.62
SLC6A2 P23975 2/20 0.62
SLC6A3 Q01959 2/20 0.62
CYP2D6 P10635 2/20 0.62
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
CYP3A4 P08684 2/20 0.50
GPR55 Q9Y2T6 2/20 0.47
TP53 P04637 1/20 0.47
HTR1A P08908 1/20 0.47
CNR1 P21554 1/20 0.47
HTR7 P34969 1/20 0.47
HTR6 P50406 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
ALDH1A1 P00352 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
HPGD P15428 1/20 0.47
LMNA P02545 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25239366 0.92 TAAR1 (0.57) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25204043 0.87 TAAR1 (0.61) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25203860 0.87 TAAR1 (0.57) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25204910 0.86 MEN1 (0.59) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25206243 0.86 TAAR1 (0.59) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25236074 0.86 MEN1 (0.59) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25233029 0.86 TAAR1 (0.59) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25203827 0.85 SLC6A4 (0.56) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25207104 0.85 MEN1 (0.54) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6
SCHEMBL25219439 0.84 MEN1 (0.53) TAAR1SLC6A4SLC6A2SLC6A3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4436964-A1 ANALOGUES OF MDMA FOR MODULATING SERT, DAT, AND / OR NET ACTIVITY The University Of Western Australia (AU) 2024-10-02 EP disclosed
WO-2023092195-A1 ANALOGUES OF MDMA FOR MODULATING SERT, DAT, AND / OR NET ACTIVITY THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2023-06-01 WO disclosed
WO-2023092195-A1 ANALOGUES OF MDMA FOR MODULATING SERT, DAT, AND / OR NET ACTIVITY THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2023-06-01 WO disclosed