Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.61 |
| ▸ | INSR | P06213 | 12/20 | 0.61 |
| ▸ | NPM1 | P06748 | 11/20 | 0.61 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519868 | 0.91 | ALK (0.74) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL519870 | 0.91 | ALK (0.74) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL519869 | 0.91 | ALK (0.74) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL2510622 | 0.88 | ALK (0.60) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL520197 | 0.87 | ALK (0.78) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL520198 | 0.87 | ALK (0.78) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL520196 | 0.87 | ALK (0.78) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL521232 | 0.83 | ALK (0.73) | ALKINSRNPM1JAK2CYP3A4 | |
| SCHEMBL2509799 | 0.82 | ALK (0.58) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL519710 | 0.82 | ALK (0.81) | ALKINSRNPM1JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |